Altered Myocardial Calcium Cycling and Energetics in Heart Failure-A Rational Approach for Disease Treatment

作者：Gorski Przemek A; Ceholski Delaine K; Hajjar Roger J^*

来源：Cell Metabolism, 2015, 21(2): 183-194.

DOI：10.1016/j.cmet.2015.01.005

Cardiomyocyte function depends on coordinated movements of calcium into and out of the cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling proteins and abnormal energy metabolism are features of heart failure. Recent discoveries have led to gene-based therapies targeting calcium-transporting or -binding proteins, such as the cardiac sarco(endo) plasmic reticulum calcium ATPase (SERCA2a), leading to improvements in calcium homeostasis and excitation-contraction coupling. Here we review impaired calcium cycling and energetics in heart failure, assessing their roles from both a mutually exclusive and interdependent viewpoint, and discuss therapies that may improve the failing myocardium.

• 出版日期2015-2-3