An aerobic [2 2 2] Cyclization via Chloropalladation: From 1,6-Diynes and Acrylates to Substituted Aromatic Carbocycles

作者：Zhou Peng; Zheng Meifang; Jiang Huanfeng^*; Li Xianwei; Qi Chaorong

来源：Journal of Organic Chemistry, 2011, 76(11): 4759-4763.

DOI：10.1021/jo200572n

• Carbocycles
• Mechanistic studies
• Reaction mechanism
• Substituted aromatic

A Pd-catalyzed aerobic [2 2 2] cyclization of 1,6-diynes and acrylates proceeding through a chloropalladation process has been developed. Polysubstituted five-membered aromatic carbocycles/heterocycles were obtained in good to excellent yields. The results of the mechanistic study are consistent with the proposed reaction mechanism.

• 出版日期2011-6-3
• 单位华南理工大学