Analysis of Circulating Cholesterol Levels as a Mediator of an Association Between ABO Blood Group and Coronary Heart Disease

作者：Chen, Yequn; Chen, Chang; Ke, Xiayi; Xiong, Longgen; Shi, Yongying; Li, Jiafu; Tan, Xuerui; Ye, Shu^*

来源：Circulation-Cardiovascular Genetics, 2014, 7(1): 43-48.

DOI：10.1161/CIRCGENETICS.113.000299

• SERUM-CHOLESTEROL
• ARTERY-DISEASE
• RISK
• SUSCEPTIBILITY
• METAANALYSIS
• POPULATION
• VARIANTS
• ALLELES
• CANCER
• COHORT

<jats:sec>
<jats:title>Background—</jats:title>
<jats:p>Non-O type of ABO blood group has been associated with a predisposition to coronary heart disease. It is thought that this association is partly mediated by increased cholesterol levels in non–O-type individuals. In this study, we sought to estimate the mediation effect size.</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Methods and Results—</jats:title>
<jats:p>
In a group of individuals (n=6476) undergoing coronary angiography, we detected associations of non-O type with significant coronary artery disease with &gt;50% stenosis in ≥1 coronary arteries (odds ratio, 1.24; 95% confidence interval, 1.10–1.39;
<jats:italic>P</jats:italic>
=2.6×10
<jats:sup>−4</jats:sup>
) and with prevalent or incident myocardial infarction (odds ratio, 1.22; 95% confidence interval, 1.09–1.37;
<jats:italic>P</jats:italic>
=1.2×10
<jats:sup>−3</jats:sup>
). Subjects of non-O type had higher levels of total cholesterol, low-density lipoprotein cholesterol, and non–high-density lipoprotein cholesterol (mean [SEM] in mmol/L: 4.931[0.021], 3.041 [0.018], and 3.805 [0.020] in non-O type compared with 4.778 [0.026], 2.906 [0.021], and 3.669 [0.024] in O type;
<jats:italic>P</jats:italic>
=3.8×10
<jats:sup>−7</jats:sup>
,
<jats:italic>P</jats:italic>
=1.5×10
<jats:sup>−7</jats:sup>
, and
<jats:italic>P</jats:italic>
=3.1×10
<jats:sup>−7</jats:sup>
, respectively). Mediation analyses indicated that 10% of the effect of non-O type on coronary artery disease susceptibility was mediated by increased low-density lipoprotein cholesterol level (
<jats:italic>P</jats:italic>
=7.8×10
<jats:sup>−4</jats:sup>
) and that 11% of the effect of non-O type on myocardial infarction risk was mediated by raised low-density lipoprotein cholesterol level (
<jats:italic>P</jats:italic>
=2.0×10
<jats:sup>−3</jats:sup>
).
</jats:p>
</jats:sec>
<jats:sec>
<jats:title>Conclusions—</jats:title>
<jats:p>In a model in which it is presumed that cholesterol is a mediator of the associations of ABO group with coronary artery disease and myocardial infarction, around 10% of the effect of non-O type on coronary artery disease and myocardial infarction susceptibility was mediated by its influence on low-density lipoprotein cholesterol level.</jats:p>
</jats:sec>

• 出版日期2014-2
• 单位南方医科大学; 广州医科大学; 汕头大学; 西南医科大学