A general route to 5-substituted-2-furylacetic acids: a brief synthesis of plakorsin B

作者：Hayes Simon J; Knight David W^*; Smith Andrew W T; O'Halloran Mark J

来源：Tetrahedron Letters, 2010, 51(4): 717-719.

DOI：10.1016/j.tetlet.2009.11.120

• 2-Furylacetic acids
• 5-endo-dig
• Silver-catalysed
• Furan
• Plakorsin

3,4-Dihydroxy-5-alkynylcarboxylic acids, readily obtained by the addition of lithium acetylides to alpha-acetoxysuccinic anhydride followed by reduction and hydrolysis, undergo smooth silver(I)-catalysed 5-endo-dig cyclisations and in situ dehydration to give excellent overall yields of 5-substituted-2-furylacetic acids, including the natural metabolite plakorsin B.

• 出版日期2010-1-27