ADS-J1 Inhibits HIV-1 Entry by Interacting with gp120 and Does Not Block Fusion-Active gp41 Core Formation

作者：Gonzalez Ortega Emmanuel; Mena Maria Pau; Permanyer Marc; Ballana Ester; Clotet Bonaventura; Este Jose A^*

来源：Antimicrobial Agents and Chemotherapy, 2010, 54(10): 4487-4492.

DOI：10.1128/AAC.00359-10

We had shown that virus resistance to ADS-J1 was associated with amino acid changes in the envelope glycoprotein, mostly located in the gp120 coding region. Time-of-addition and endocytic virus transfer assays clearly demonstrated that ADS-J1 behaved as a gp120 inhibitor. ADS-J1-resistant virus was cross-resistant to the polyanion dextran sulfate, and recombination of gp120 recovered only the ADS-J1-resistant phenotype. In summary, ADS-J1 blocks an early step of virus entry that appears to be driven by gp120 alone.

• 出版日期2010-10