Nanocomposites Containing Silica-Coated Gold-Silver Nanocages and Yb-2,4-Dimethoxyhematoporphyrin: Multifunctional Capability of IR-Luminescence Detection, Photosensitization, and Photothermolysis

作者：Khlebtsov Boris; Panfilova Elizaveta; Khanadeev Vitaly; Bibikova Olga; Terentyuk Georgy; Ivanov Andrey; Rumyantseva Valentina; Shilov Igor; Ryabova Anastasia; Loshchenov Victor; Khlebtsov Nikolai G^*

来源：ACS Nano, 2011, 5(9): 7077-7089.

DOI：10.1021/nn2017974

• plasmonic nanoparticles
• nanocomposites
• photodynamic therapy
• hematoporphyrin
• theranostics
• HeLa cells
• xenografted mouse tumor model

We describe novel composite nanoparticles consisting of a gold-silver nanocage core and a mesoporous silica shell functionalized with the photodynamic sensitizer Yb-2,4-dimethoxyhematoporphyrin (Yb-HP). In addition to the long-wavelength plasmon resonance near 750-800 nm, the composite particles exhibited a 400-nm absorbance peak and two fluorescence peaks, near 580 and 630 nm, corresponding to bound Yb-HP. The fabricated nanocomposites generated singlet oxygen under 630-nm excitation and produced heat under laser irradiation at the plasmon resonance wavelength (750-800 nm). In particular, we observed enhanced killing of Hela cells Incubated with nanocomposites and irradiated by 630-nm light. Furthermore, an additional advantage of fabricated conjugates was an IR-luminescence band (900-1060 nm), originating from Yb(3+) ions of bound Yb-HP and located in the long-wavelength part of the tissue transparency This modality was used to control the accumulation and biodistribution of composite particles in mice bearing Ehrlich carcinoma tumors In a comparative study with intravenously injected free Yb-HP molecules. Thus, these multifunctional nanocomposites seem an attractive theranostic platform for simultaneous IR-luminescence diagnostic and photodynamic therapy owing to Yb-HP and for plasmonic photo: thermal therapy owing to Au-Ag nanocages.

• 出版日期2011-9