Analysis of Cyclin-Dependent Kinase Inhibitor-2B rs1063192 Polymorphism in Saudi Patients with Primary Open-Angle Glaucoma

作者：Abu Amero Khaled K^*; Kondkar Altaf A; Mousa Ahmed; Almobarak Faisal A; Alawad Abdullah; Altuwaijri Saleh; Sultan Tahira; Azad Taif A; Al Obeidan Saleh A

来源：Genetic Testing and Molecular Biomarkers, 2016, 20(10): 637-641.

DOI：10.1089/gtmb.2016.0140

• CDKN2B
• genetics
• primary open angle glaucoma
• rs1063192
• Saudi Arabia

Aims: To investigate whether the polymorphism rs1063192 (A>G) in the cyclin-dependent kinase Inhibitor-2B (CDKN2B) gene is a risk factor for primary open-angle glaucoma (POAG). Method: A case-control study was conducted wherein we genotyped 87 unrelated POAG cases and 94 control subjects from Saudi Arabia using the Taq-Man((R)) assay. Results: The minor allele frequency was 0.20 in POAG cases and 0.21 in controls. Both the genotype and allele frequencies were not significantly different between cases and controls. No significant association was found between genotypes and glaucoma clinical indices, except that the mutant homozygous genotype (G/G) was associated with the family history of glaucoma (p=0.024). Conclusion: Polymorphism rs1063192 in CDKN2B is not a risk factor for POAG in Saudi cohort.

• 出版日期2016-10