Discrimination of disease-related non-synonymous single nucleotide polymorphisms using multi-scale RBF kernel fuzzy support vector machine

作者：Ju Wen; Shan Juan; Yan Changhui; Cheng H D^*

来源：Pattern Recognition Letters, 2009, 30(4): 391-396.

DOI：10.1016/j.patrec.2008.11.003

• Multi-scale RBF kernel
• Membership function
• Fuzzy support vector machine (FSVM)
• Non-synonymous single nucleotide polymorphisms (nsSNPs)

In this paper, we develop a multi-scale RBF kernel fuzzy support vector machine (MSKFSVM) and apply it to the identification of disease-associated non-synonymous single nucleotide polymorphisms (nsSNPs). The experimental results show that the proposed MSKFSVM outperforms the traditional SVM method.

• 出版日期2009-3-1