Association between beta-Lactamase-Encoding bla(OXA-51) Variants and DiversiLab Rep-PCR-Based Typing of Acinetobacter baumannii Isolates

作者：Zander Esther; Nemec Alexandr; Seifert Harald; Higgins Paul G^*

来源：Journal of Clinical Microbiology, 2012, 50(6): 1900-1904.

DOI：10.1128/JCM.06462-11

This study investigated the correlation between bla(OXA-51) variants and Acinetobacter baumannii worldwide clonal lineages 1 to 8 (WW1 to -8). The bla(OXA-51-like) genes of 102 A. baumannii isolates were sequenced. Using DiversiLab repetitive-sequence-based PCR (rep-PCR) typing, 92 of these isolates had previously been assigned to WW1 to -8 and 10 were unclustered. Clustering of DNA sequences was performed using the neighbor-joining method and the Jukes-Cantor phylogenetic correction. bla(OXA-51) variants were in good correlation with DiversiLab-defined clonal lineages. Sequence-based typing of bla(OXA-51) variants has the potential to be applied for epidemiologic characterization of A. baumannii and to identify worldwide clonal lineages 1 to 8.

• 出版日期2012-6
• 单位河北医科大学