Lymphangioleiomyomatosis observed in the dissected lymph node and myometrium in a patient that underwent radical operation for endometrial cancer

作者：Morita H^*; Miyahara Y; Ueno Y; Otani K; Kawakami F; Ebina Y; Yamada H

来源：European Journal of Gynaecological Oncology, 2017, 38(5): 815-817.

DOI：10.12892/ejgo3709.2017

• Lymphangioleiomyomatosis
• Endometrial cancer
• Lymph node
• Myometrium
• Tuberous sclerosis

Lymphangioleiomyomatosis (LAM) is a rare disease that afflicts mostly young women. It is characterized pathologically by the appearance of interstitial collections of atypical smooth muscle cells and cyst formation in the lungs, lymph node, kidney, and so on. A case was presented that underwent radical operation with the diagnosis of endometrial cancer, in which were found LAM cells in dissected lymph node and myometrium. Case: A 40-year-old woman underwent radical operation with the diagnosis of endometrial cancer. Although the dissected pelvic and para-aortic lymph nodes did not show the metastases of cancer, immunohistochemical study revealed the LAM cells among the dissected lymph nodes. Further histological study showed the LAM cells were in the uterine myometrium as well. Physical examination excluded the diagnosis of tuberous sclerosis. Since pulmonary LAM were observed as well, the physician followed the patient. Discussion: Sporadic LAM, without a complication of tuberous sclerosis, rarely shows LAM cells systemically as in this case. Conclusions: When LAM is observed coincidentally in operated dissected lymph node, it is important to examine for tuberous sclerosis and also to follow up the fmdings in the lung.

• 出版日期2017