Accurate information transmission through dynamic biochemical signaling networks

作者：Selimkhanov Jangir; Taylor Brooks; Yao Jason; Pilko Anna; Albeck John; Hoffmann Alexander; Tsimring Lev; Wollman Roy^*

来源：Science, 2014, 346(6215): 1370-1373.

DOI：10.1126/science.1254933

Stochasticity inherent to biochemical reactions (intrinsic noise) and variability in cellular states (extrinsic noise) degrade information transmitted through signaling networks. We analyzed the ability of temporal signal modulation-that is, dynamics-to reduce noise-induced information loss. In the extracellular signal-regulated kinase (ERK), calcium (Ca2+), and nuclear factor kappa-B (NF-kappa B) pathways, response dynamics resulted in significantly greater information transmission capacities compared to nondynamic responses. Theoretical analysis demonstrated that signaling dynamics has a key role in overcoming extrinsic noise. Experimental measurements of information transmission in the ERK network under varying signal-to-noise levels confirmed our predictions and showed that signaling dynamics mitigate, and can potentially eliminate, extrinsic noise-induced information loss. By curbing the information-degrading effects of cell-to-cell variability, dynamic responses substantially increase the accuracy of biochemical signaling networks.

• 出版日期2014-12-12