A STOCHASTIC MARKOV MODEL OF CELLULAR RESPONSE TO RADIATION

作者:Fornalski Krzysztof Wojciech*; Dobrzynski Ludwik; Janiak Marek Krzysztof
来源:Dose-Response, 2011, 9(4): 477-496.
DOI:10.2203/dose-response.11-003.Fornalski

摘要

A stochastic model based on the Markov Chain Monte Carlo process is used to describe responses to ionizing radiation in a group of cells. The results show that where multiple relationships linearly depending on the dose are introduced, the overall reaction shows a threshold, and, generally, a non-linear response. Such phenomena have been observed and reported in a number of papers. The present model permits the inclusion of adaptive responses and bystander effects that can lead to hormetic effects. In addition, the model allows for incorporating various time-dependent phenomena. Essentially, all known biological effects can be reproduced using the proposed model.

  • 出版日期2011