Novel and facile synthesis of 1-benzazepines via copper-catalyzed oxidative C(sp3)-H/C(sp2)-H cross-coupling

作者：Wang, Rui; Jin, Ruo-Xing; Qin, Zi-Yang; Bian, Kang-Jie; Wang, Xi-Sheng^*

来源：Chemical communications, 2017, 53(90): 12229-12232.

DOI：10.1039/c7cc07027f

• FUSED 1-BENZAZEPINES
• AMINO-ALCOHOLS
• CYCLIZATION
• HETEROCYCLES
• DERIVATIVES
• INHIBITORS
• ALKANES
• POTENT
• ROUTE
• HETEROAROMATICS

A novel and facile synthetic strategy for the construction of 1-benzazepines has been developed via copper-catalyzed oxidative C(sp(3))-H/C(sp(2))-H cross-coupling directly from two inert C-H bonds. This transformation represents an atom-and step-economical way to synthesize biologically important seven-membered benzo-heterocycles compared with the known methods.

• 出版日期2017-11-21
• 单位中国科学技术大学