科研之友
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摘要
This review focuses on exogenous magnetic resonance imaging (MRI) contrast agents that are responsive to enzyme activity. Enzymes can catalyze a change in water access, rotational tumbling time, the proximity of a F-19-labeled ligand, the aggregation state, the proton chemical-ex-change rate between the agent and water, or the chemical shift of F-19, P-31, C-13 or a labile H-1 of an agent, all of which can be used to detect enzyme activity. The variety of agents attests to the creativity in developing enzyme-responsive MRI contrast agents.
- 出版日期2014-8-4
