Association between nesfatin-1 levels and metabolic improvements in severely obese patients who underwent biliopancreatic derivation with duodenal switch

作者：St Pierre David H; Martin Julie; Shimizu Hiroyuki; Tagaya Yuko; Tsuchiya Takahumi; Marceau Simon; Biertho Laurent; Bastien Marjorie; Caron Cantin Sarah Maude; Simard Serge; Richard Denis; Cianflone Katherine; Poirier Paul

来源：Peptides, 2016, 86: 6-12.

DOI：10.1016/j.peptides.2016.09.014

• Nesfatin-1
• Biliopancreatic diversion with duodenal switch
• Type 2 diabetes
• Cardiometabolic health

Context: Nesfatin-1 is a neuroendocrine peptide with potent anorexigenic activity in rodents. The potential role of nesfatin-1 on the regulation of energy balance, metabolic functions and inflammation is currently debated in obese humans. In the present study, nesfatin-1 fluctuations and their associations with metabolic factors were investigated in severely obese patients who underwent biliopancreatic diversion with duodenal switch (BPD/DS) and severely obese controls (SOC).
Basic procedures: Sixty severely obese patients who underwent BPD/DS and 15 SOC (matched for BMI and age) were included in the study. Associations between nesfatin-1 levels and body composition, glucose metabolism, lipid profile as well as inflammatory markers were evaluated at baseline and over a postsurgeryl 2-month (12 M) period.
Main findings: Body weight was reduced at 6 M and at 12 M in BPD/DS patients (P< 0.001). Nesfatin-1 levels were reduced at 6 M (women: P < 0.05) and at 12 M (men and women; 0.001) in BPD/DS patients. At baseline, nesfatin-1 levels negatively correlated with weight, fat (FM) and fat-free mass (FFM) in the whole population (combined BPD/DS and SOC patients). At 12 M, nesfatin-1 concentrations positively correlated with weight, FM, fasting insulin, insulin resistance, total cholesterol, LDL-cholesterol, triglyceride and apoB values. At 12 M, % changes in nesfatin-1 were positively associated with% changes in weight, FM, FFM, fasting insulin, insulin resistance, total cholesterol, LDL-cholesterol, apoB and C-reactive protein.
Conclusion: Nesfatin-1 levels decrease following BPD/DS-induced weight loss and are significantly associated with parameters of metabolic health.

• 出版日期2016-12