An efficient synthesis of substituted cytosines and purines under focused microwave irradiation

作者：Huang Ling Kuen; Cherng Yen Chih; Cheng Yann Ru; Jang Jing Pei; Chao Yi Ling; Cherng Yie Jia^*

来源：Tetrahedron, 2007, 63(24): 5323-5327.

DOI：10.1016/j.tet.2007.02.124

• nucleophilic displacement
• focused microwave irradiation
• cytosine
• purine

A rapid nucleophilic displacement reaction of 6-chloropurine, 2-amino-6-chloropurine and 5-bromocytosine with various nucleophiles under focused microwave irradiation is described. Using this method, the desired products were obtained with the yields up to 99% in a short reaction time.

• 出版日期2007-6-11