One-pot efficient synthesis of aryl alpha-keto esters from aryl-ketones

作者：Zhuang, Jing; Wang, Changqing; Xie, Fang; Zhang, Wanbin^*

来源：Tetrahedron, 2009, 65(47): 9797-9800.

DOI：10.1016/j.tet.2009.09.076

• One-pot
• Aryl alpha-keto esters
• Selenium dioxide
• Ketalization

A novel one-pot synthesis of aryl alpha-keto esters was developed through oxidation of aryl-ketones using selenium dioxide, esterification accompanied by ketalization, and hydrolysis. Both aromatics and heteroaromatics gave good yields by this one-pot method.

• 出版日期2009-11-21
• 单位上海交通大学