New Strategies for Multimodality Therapy in Treating Locally Advanced Cervix Cancer

作者：Verma Jonathan; Monk Bradley J; Wolfson Aaron H^*

来源：Seminars in Radiation Oncology, 2016, 26(4): 344-348.

DOI：10.1016/j.semradonc.2016.05.003

Cervical cancer is the fourth most common cause of cancer of women worldwide. In the developing world, it comprises 12% of all cancers of women. Since 1999, the mainstay of treatment for locally advanced cervical cancer (LACC) has been concurrent cisplatin-based chemoradiation. However, outcomes in this disease remain suboptimal, with long-term progression-free survival and overall survival rates of approximately 60%. There are several new strategies of combined modality treatment under evaluation in LACC, including chemotherapy before and after treatment as well as novel agents such as poly-adenosine diphosphate ribose polymerase inhibitors, antiangiogenic blockage, and immunotherapy. We provide a brief overview of these strategies and their potential in the treatment of women with LACC.

• 出版日期2016-10