科研之友
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摘要
The aim of the present study was to investigate the toxicological mechanism of microcystin-LR (MC-LR) on HepG2 cells to understand MC-related human hepatitis and primary liver cancer. The results showed that MC-LR induced the time- and concentration-dependent apoptosis of HepG2 cells, and MC-LR exposure promoted the expression of Smac/Diablo in HepG2 cells. In addition, Bad and cleaved-Bid protein levels were also altered. Moreover, MC-LR exposure promoted the expression of Fas and FasL and increased caspase-8 transcription and enzymatic activity, suggesting that the MC-LR-induced apoptosis of HepG2 cells may be mediated via mitochondrial and Fas/FasL pathways in which lysosomal destabilization might play an important role.
- 出版日期2017
- 单位河南师范大学
