科研之友
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摘要
Background: The etiopathogenesis of Hashimoto's thyroiditis (HT) - has not been clearly elucidated although the role of chronic inflammation, endothelial dysfunction, and imbalance between pro- and anti-inflammatory cytokines has been established. Transforming growth factor beta 1 (TGF beta 1) is required to maintain immune homeostasis, and is implicated in lymphocyte infiltration, production of autoantibodies and thyrocyte destruction seen in patients with HT. Aim: The aim of the present study was to investigate the possible association of Leu10Pro (c.869T>C) and Arg25Pro (c.915G>C) single nucleotide polymorphisms (SNPs) of TGE beta 1 gene with the occurrence of HT. Methods: We analyzed the genotype and allele frequencies of polymorphisms at codon 10 and 25 in 178 patients who had been diagnosed as having HT and 197 healthy controls using PCR-restriction fragment length polymorphism (RFLP). Results: There was no notable risk for HT afflicted by Leul OPro (c.869T>C) polymorphism of TG beta 1 gene. However, there was a significant increase of Arg25Pro (c.915G>C) C allele frequency in patients with HT compared with healthy controls (p = 0.003, OR = 1.87,95% CI = 1.23-2.84). Moreover, heterozygous (CG) subjects had a 2.53-fold increased risk for developing HT with respect to wild (GG) homozygotes (p < 0.001, 95% CI = 1.57-4.05). TSH levels in CG heterozygous patients were increased in comparison with wild homozygotes (p = 0.006). Conclusion: This study indicates that the Arg25Pro (c.915G>C) polymorphism of TGF beta 1 gene may be related to increased risk for HT.
- 出版日期2015-9
