MuSK autoantibodies in myasthenia gravis detected by cell based assay - A multinational study

作者：Tsonis A I; Zisimopoulou P^*; Lazaridis K; Tzartos J; Matsigkou E; Zouvelou V; Mantegazza R; Antozzi C; Andreetta F; Evoli A; Deymeer F; Saruhan Direskeneli G; Durmus H; Brenner T; Vaknin A; Berrih Aknin S; Behin A; Sharshar T; De Baets M; Losen M; Martinez Martinez P; Kleopa K A; Zamba Papanicolaou E; Kyriakides T; Kostera Pruszczyk A; Szczudlik P; Szyluk B; Lavrnic D; Basta I; Peric S; Tallaksen C; Maniaol A; Pons C Casasnovas

来源：Journal of Neuroimmunology, 2015, 284: 10-17.

DOI：10.1016/j.jneuroim.2015.04.015

• Myasthenia gravis
• MuSK
• Autoantibodies
• Cell based assay
• Diagnosis

Seronegative myasthenia gravis (MG) presents a serious gap in MG diagnosis and understanding. We applied a cell based assay (CBA) for the detection of muscle specific kinase (MuSK) antibodies undetectable by radioimmunoassay. We tested 633 triple-seronegative MG patients' sera from 13 countries, detecting 13% as positive. MuSK antibodies were found, at significantly lower frequencies, in 1.9% of healthy controls and 5.1% of other neuroimmune disease patients, including multiple sclerosis and neuromyelitis optica. The clinical data of the newly diagnosed MuSK-MG patients are presented. 27% of ocular seronegative patients were MuSK antibody positive. Moreover, 23% had thymic hyperplasia suggesting that thymic abnormalities are more common than believed.

• 出版日期2015-7-15