科研之友
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摘要
An efficient approach to a new family of highly functionalized P analogues of alpha-trifluoromethyl-substituted phenylalanine and its homologues using ruthenium-catalyzed intermolecular ene-yne metathesis as a key step of the reaction sequence has been developed. The method includes cross metathesis of alpha-alkynyl-alpha-trifluoromethyl-alpha-aminophosphonates with alkenes under catalysis by second-generation Grubbs carbene complex to afford the corresponding aminophosphonates with 1,3-diene backbone followed by one-pot Diels-Alder reaction-aromatization step.
- 出版日期2014-11
