A convenient synthesis of 2-aryl substituted benzo[f][1,2,4]triazolo[1,5-a]azepine derivatives

作者：Meng, Qing Qing; Bai, He Xiang; Li, Feng; Wang, Quan Rui^*; Tao, Feng Gang

来源：Chinese Chemical Letters, 2007, 18(7): 785-787.

DOI：10.1016/j.cclet.2007.05.005

• benzotriazoloazerpine
• nitriles
• 1,3-dipolar cycloaddition
• ring expansion

A convenient synthetic pathway to 2-aryl-5,6-dihydro-4H-benzoV][1,2,4]triazolo[1,5-a]azepine derivatives 7 was developed. The synthesis was based on the cycloaddition of the 1,2,3,4-tetrahydronaphthalene u-acetoxy azo compounds 3 with Ar-CN in the presence of AICl(3) and the consecutive ring enlargement.

• 出版日期2007-7
• 单位复旦大学