Marker-based ballistocardiographic artifact correction improves spike identification in EEG-fMRI of focal epilepsy patients

作者：Koerbl Katharina; Jacobs Julia; Herbst Michael; Zaitsev Maxim; Schulze Bonhage Andreas; Hennig Juergen; LeVan Pierre

来源：Clinical Neurophysiology, 2016, 127(8): 2802-2811.

DOI：10.1016/j.clinph.2016.05.361

• Ballistocardiographic artifact correction
• Epileptic spike/IED
• Refractory epilepsy
• EEG-fMRI
• Fast fMRI
• Optical tracking
• MPT marker

Objectives: Ballistocardiographic (BCG) artifacts resemble interictal epileptic discharges (IEDs) and can lead to incorrect IED identification in EEG-fMRI. This study investigates IEDs marked in EEGs corrected using information from a moire phase tracking (MPT) marker.
Methods: EEG-fMRI from 18 patients was processed with conventional methods for BCG removal, while 9 patients used a MPT marker. IEDs were marked first without ECG information. In a second review, suspicious IEDs synchronous with the BCG were discarded. After each review, an event-related fMRI analysis was performed on the marked IEDs.
Results: No difference was found in the proportion of suspicious IEDs in the 2 patient groups. However, the distribution of IED timings was significantly related to the cardiac cycle in 11 of 18 patients recorded without MPT marker, but only 2 of 9 patients with marker. In patients recorded without marker, failing to discard suspicious IEDs led to more inaccurate fMRI maps and more distant activations.
Conclusions: BCG artifact correction based on MPT recordings allowed a more straightforward identification of IEDs that did not require ECG information in the large majority of patients.
Significance: Marker-based ballistocardiographic artifact correction greatly facilitates the study of the generators of interictal discharges with EEG-fMRI.

• 出版日期2016-8