Novel benzimidazole-pyrimidine conjugates as potent antitumor agents

作者：Abdel Mohsen Heba T^*; Ragab Fatma A F; Ramla Mostafa M; El Diwani Hoda I

来源：European Journal of Medicinal Chemistry, 2010, 45(6): 2336-2344.

DOI：10.1016/j.ejmech.2010.02.011

• Synthesis
• Benzimidazole
• Pyrimidine
• Antitumor activity

As a continuation to our previous work in synthesizing antitumor benzimidazoles, a series of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-(substituted)-6-phenylpyrimidine-5-carbonitriles was synthesized. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against twelve cell lines namely, Cervical carcinoma (KB), Ovarial carcinoma (SK OV-3), CNS cancer (SF-268), Non small lung cancer (NCI H460), Colonadenocarcinoma (RKOP27), Leukaemia (HL60, U937, K562), Melanoma (G361, SK-MEL-28) and Neuroblastoma (GOTO, NB-1) revealed their marked potency when compared with known anticancer drugs.

• 出版日期2010-6