Association of clinical trial enrollment and survival using contemporary therapy for pediatric acute lymphoblastic leukemia

作者：Moke Diana J; Oberley Matthew J; Bhojwani Deepa; Parekh Chintan^*; Orgel Etan

来源：Pediatric Blood and Cancer, 2018, 65(2): e26788.

DOI：10.1002/pbc.26788

• clinical trial enrollment
• clinical trial participation
• disparities
• pediatric B-cell acute lymphoblastic leukemia
• survival

While early studies reported superior survival for cancer patients enrolled on clinical trials, recent findings are inconclusive. We investigated the association between enrollment on contemporary trials and event-free survival (EFS) in pediatric B-cell acute lymphoblastic leukemia (B-ALL). In a retrospective cohort of 274 children (1-21 years) treated for B-ALL from 2008 to 2015, 55.5% enrolled with no disparity in enrollment by age, sex, or ethnicity. Three-year EFS was similar for enrolled and not enrolled patients (90.1% [95% CI, 82.5-94.5] versus 86.5% [95% CI, 77.7-92.0]). Clinical trial enrollment did not affect pediatric B-ALL survival, albeit in a limited-size cohort treated at a single academic institution.

• 出版日期2018-2