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摘要
The response of resonant-mode cantilever sensors depends on the binding strength of analyte mass to the sensor surface. Comparison of cantilever response to attachment of three macrosized pieces: quartz [300 and 600 mu g, water contact angle (Phi) = 10 degrees], silanized quartz (300 mu g, Phi = 99 degrees), and polytetrafluoroethylene (1.5 mg, Phi = 85 degrees), with water and ethanol films indicates that the resonance frequency decrease is larger for higher liquid surface tension and lower contact angle. For example, quartz piece (1 X 1 X 0.160 mm(3), L X W X H) weighing 300 mu g caused a 1987 +/- 214 Hz (n = 22) decrease in the resonance frequency with a water film while the hydrophobic silanized quartz caused a significantly lower frequency shift of 1218 +/- 187 Hz (n = 22).
- 出版日期2011-3-14
