A 28-day oral toxicity study of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, in F344 rats

作者：Hagiwara Akihiro^*; Imai Norio; Sano Masashi; Kawabe Mayumi; Tamano Seiko; Kitamura Satoshi; Omoto Toshio; Asai Iwao; Yasuhara Kazuo; Hayashi Shim mo

来源：Journal of Toxicological Sciences, 2010, 35(3): 317-325.

• Fermentation-derived cellulose
• Food additive
• Subacute toxicity
• F344 rats

This study was designed to evaluate any adverse effect of fermentation-derived cellulose, produced by Acetobacter aceti subspecies xylinum, when administered to both sexes of F344 rats at dietary levels of 0, 1.25, 2.5, and 5.0% for 28 days. The treatment had no adverse effects on clinical signs, mortality, body weights and food and water consumption, or on urinalysis, ophthalmology, hematology, blood biochemistry, and histopathology findings. At necropsy, slight increased absolute and relative cecum weights, evident in females ingesting 2.5% and 5.0% dietary levels, were considered to be a physiological adaptation to the poorly absorbed fermentation-derived cellulose. The non-observed-adverse-effect level (NOAEL) from the present study was concluded to be 5.0% in the diet (5,331 mg/kg body weights/day for males, and 5,230 mg/kg body weights/day for females).

• 出版日期2010-6
• 单位河北医科大学