An Instantaneous Low-Cost Point-of-Care Anemia Detection Device

作者：Punter Villagrasa Jaime^*; Cid Joan; Paez Aviles Cristina; Rodriguez Villarreal Ivon; Juanola Feliu Esteve; Colomer Farrarons Jordi; Miribel Catala Pere Ll

来源：Sensors (Switzerland), 2015, 15(2): 4564-4577.

DOI：10.3390/s150204564

We present a small, compact and portable device for point-of-care instantaneous early detection of anemia. The method used is based on direct hematocrit measurement from whole blood samples by means of impedance analysis. This device consists of a custom electronic instrumentation and a plug-and-play disposable sensor. The designed electronics rely on straightforward standards for low power consumption, resulting in a robust and low consumption device making it completely mobile with a long battery life. Another approach could be powering the system based on other solutions like indoor solar cells, or applying energy-harvesting solutions in order to remove the batteries. The sensing system is based on a disposable low-cost label-free three gold electrode commercial sensor for 50 mu L blood samples. The device capability for anemia detection has been validated through 24 blood samples, obtained from four hospitalized patients at Hospital Clinic. As a result, the response, effectiveness and robustness of the portable point-of-care device to detect anemia has been proved with an accuracy error of 2.83% and a mean coefficient of variation of 2.57% without any particular case above 5%.

• 出版日期2015-2