Prolonged treatment with valganciclovir in an infant with congenital cytomegalovirus infection

作者：Baquero Artigao F^*; Romero Gomez M P

来源：Anales de Pediatria, 2009, 70(6): 578-581.

DOI：10.1016/j.anpedi.2009.01.010

• Congenital cytomegalovirus
• Symptomatic infection
• Hearing loss
• Ganciclovir
• Valganciclovir

Treatment with intravenous ganciclovir for six weeks prevents hearing deterioration in children with symptomatic congenital cytomegalovirus (CMV) infection. Prolonged treatment might be more beneficial, but is associated with the potential side-effects of tong-term use of intravenous lines. Oral valganciclovir could be an alternative because of its excellent bio-availability, reaching plasma concentrations similar to those achieved with intravenous ganciclovir in neonates with symptomatic CMV infection. We present a two-month-old girt with congenital CMV infection with central nervous disease involvement, who was treated with intravenous ganciclovir for 15 days followed by oral valganciclovir (30 mg/kg/day in 2 doses) for 6 months. Treatment resulted in adequate ganciclovir plasma levels, suppressed plasma viral toad, prevention of hearing deterioration and was well tolerated, with no apparent side-effects.

• 出版日期2009-6