Association of ABO Blood Group and Risk of Lung Cancer in a Multicenter Study in Turkey

作者：Urun Yuksel^*; Utkan Gungor; Cangir Ayten Kayi; Oksuzoglu Omur Berna; Ozdemir Nuriye; Oztuna Derya Gokmen; Kocaman Gokhan; Coskun Hasan Senol; Kaplan Muhammet Ali; Yuksel Cabir; Demirkazik Ahmet; Icli Fikri

来源：Asian Pacific Journal of Cancer Prevention, 2013, 14(5): 2801-2803.

DOI：10.7314/APJCP.2013.14.5.2801

• ABO blood
• group system
• lung neoplasms
• cancer
• risk factors

Background: The ABO blood groups and Rh factor may affect the risk of lung cancer. Materials and Methods: We analyzed 2,044 lung cancer patients with serologically confirmed ABO/Rh blood group. A group of 3,022,883 healthy blood donors of Turkish Red Crescent was identified as a control group. We compared the distributions of ABO/Rh blood group between them. Results: The median age was 62 years (range: 17-90). There was a clear male predominance (84% vs. 16%). Overall distributions of ABO blood groups were significantly different between patients and controls (p=0.01). There were also significant differences between patients and controls with respect to Rh positive vs. Rh negative (p=0.04) and O vs. non-O (p=0.002). There were no statistically significant differences of blood groups with respect to sex, age, or histology. Conclusions: In the study population, ABO blood types were associated with the lung cancer. Having non-O blood type and Rh-negative feature increased the risk of lung cancer. However, further prospective studies are necessary to define the mechanisms by which ABO blood type may influence the lung cancer risk.

• 出版日期2013