Analysis of Nanafrocin in Foodstuffs of Animal Origin by LC-MS-MS

作者：Cheng, Kaipeng; Wang, Sufang^*; Guo, Kangquan; Zhang, Dongfei; Guo, Junfeng; Sun, Wuyong; Hu, Yaohua

来源：Chromatographia, 2010, 71(5-6): 389-395.

DOI：10.1365/s10337-009-1449-5

• Column liquid chromatography-mass spectrometry
• Nanafrocin
• Veterinary drug

A new, rapid, and efficient method, multiple reaction monitoring liquid chromatography-tandem mass spectrometry, has been developed for analysis of nanafrocin in foodstuffs of animal origin. The researchers used a C-18 stationary phase coupled with triple-quadrupole tandem mass spectrometry in negative-electrospray mode. The limits of detection (LOD) and quantification (LOQ) were 0.005 and 0.01 mg kg(-1), respectively, in the matrixes. Detector response was found to be a linear function of concentration over the range 0.005-0.1 mg kg(-1) in each matrix. Mean overall recovery (n = 10) of nanafrocin varied from 71 to 101%. The results show that identification and quantification of nanafrocin residues in foodstuffs of animal origin can be successfully achieved by use of the proposed LC-MS-MS method.

• 出版日期2010-3
• 单位河南出入境检验检疫局检验检疫技术中心; 西北农林科技大学