Nickel-catalyzed C-H activation of purine bases with alkyl halides

作者:Ruan Zhixiong; Ghorai Debasish; Zanoni Giuseppe; Ackermann Lutz
来源:Chemical Communications, 2017, 53(65): 9113-9116.
DOI:10.1039/c7cc05011a

摘要

C-H alkylations of purine nucleosides were achieved by means of user-friendly nickel catalysis with ample substrate scope and high levels of chemo, site and regio control, which among others enabled the direct fluorescent labeling of purines in terms of late stage diversification.

  • 出版日期2017-8-21