A Catalytic Route to Ampakines and Their Derivatives

作者：Mulzer Michael; Coates Geoffrey W^*

来源：Organic Letters, 2011, 13(6): 1426-1428.

DOI：10.1021/ol200111a

A catalytic domino reaction that efficiently provides access to an important class of heterocycles, the ampakines, is reported. Our approach Is based on the cobalt-catalyzed hydroformylation of dihydrooxazines and allows for the facile synthesis of the pharmaceutically interesting compound CX-614 and related substances.

• 出版日期2011-3-18