Botulinum Toxin A Treatment in Spastic Forms of Cerebral Palsy: A Retrospective Clinical Study

作者：Fujak A^*; Koeckeritz S; Haeberle L; Desman C; Lorenz I; Koeckeritz J; Forst R; Forst J

来源：Zeitschrift fur Orthopadie und Unfallchirurgie, 2012, 150(2): 181-189.

DOI：10.1055/s-0031-1298259

• cerebral palsy
• botulinum toxin
• spasticity
• quality of life
• anaesthesia

Background: Botulinum toxin therapy now has a firm place in the treatment of spastic forms of cerebral palsy in children. This paper considers the subjective and practical results and the degrees of satisfaction from the point of view of the patients and their families. It also documents the data of infiltrations carried out under anaesthesia. %26lt;br%26gt;Patients and Methods: 57 patients with an average age of 11 (+/-6.7; 2-30) and with infantile spastic cerebral palsy underwent altogether 118 botulinum toxin A infiltrations. The patients were divided into two groups: those with spastic hemiparesis or diparesis, and those with tetraparesis, and then compared with each other. The results of the treatment were evaluated from the point of view of the patients and their families with the help of a specially developed questionnaire. %26lt;br%26gt;Results: The study shows that, broadly-speaking, patients less affected with spastic hemiparesis or diparesis felt they profited more from the treatment than patients more severely affected with tetraparesis. The statistics also show that the first group%26apos;s expectations were significantly more often fulfilled and that they more frequently perceived greater success after each infiltration than the group with tetraparesis. Most patients and their families from both groups were satisfied with the treatment. %26lt;br%26gt;Conclusion: Patients and their families feel that the use of botulinum toxin in the management of spastic cerebral palsy in children is an effective and accepted form of treatment. The aims of the therapy should be defined accurately and realistically before starting treatment, especially for those severely affected with tetraparesis, and discussed in detail with both the patient and his/her family.

• 出版日期2012-4
• 单位河北医科大学