Chromophenazines from the Terrestrial Streptomyces sp Ank 315

作者：Zendah Imene; Riaz Naheed; Nasr Hamdi; Frauendorf Holm; Schueffler Anja; Raies Aly; Laatsch Hartmut^*

来源：Journal of Natural Products, 2012, 75(1): 2-8.

DOI：10.1021/np100818d

The new chromophenazines A-F [9-methyl-5-(3%26apos;-methylbut-2%26apos;-enyl)-5H-benzo[a]phenazin-7-one (la), 9-methyl-5-(3%26apos;-methylbut-2%26apos;-enyl)-7-oxo-5,7-dihydrobenzo [a]phenazine-1-carboxylic acid (1b), 5-(3%26apos;-methylbut-2%26apos;-eny1)-7-oxo-5,7-dihydrophenazine-l-carboxamide (2), 3-benzoyl-5-(3%26apos;-methylbut-2%26apos;-enyl)-5,10-dihydrophenazine-1-carboxylic acid (5a), 3,7-dibenzoyl-5-(3%26apos;-methylbut-2%26apos;-enyl)-5,10-dihydrophenazine-1-carboxylic acid (5b), and 3,7-dibenzoyl-5-(3%26apos;-methylbut-2%26apos;-enyl)-5,10-dihydrophenazine-1-carboxamide (5c)], together with phenazine-1-carboxylic acid, 1-phenazinecarboxamide, 1-phenazinol, tryptophol, and anthranilic acid, were isolated from Streptomyces sp. Ank 315. The structures of the new compounds were established on the basis of spectroscopic data, 1D NOE, 2D NMR, and ESIMS measurements and comparison with literature values.

• 出版日期2012-1