Asymmetric synthesis of 2-substituted pyrrolidines by addition of Grignard reagents to gamma-chlorinated N-tert-butanesulfinyl imine

作者：Reddy Leleti Rajender^*; Prashad Mahavir

来源：Chemical Communications, 2010, 46(2): 222-224.

DOI：10.1039/b917435d

A highly diastereoselective addition of various Grignard reagents to chiral gamma-chlorinated N-tert-butanesulfinyl imine resulting in the formation of 2-substituted pyrrolidines is reported. This method is general and also efficient for the preparation of both enantiomers of 2-aryl, 2-alkyl and 2-vinyl substituted pyrrolidines in high yields.

• 出版日期2010