Maternal and fetal outcomes of pregnancy with Fontan circulation: A multicentric observational study

作者：Gouton Marielle; Nizard Jacky; Patel Mehul; Sassolas Francois; Jimenez Maria; Radojevic Jelena; Mathiron Amel; Amedro Pascal; Barre Elise; Labombarda Fabien; Vaksmann Guy; Chantepie Alain; Le Gloan Laurianne; Ladouceur Magalie^*

来源：International Journal of Cardiology, 2015, 187: 84-89.

DOI：10.1016/j.ijcard.2015.03.344

• Pregnancy
• Fontan circulation
• Congenital heart disease
• Anticoagulation

Background: Despite serious long-term sequel, women with Fontan palliation have reached childbearing age. However there is paucity of data on the pregnancy outcomes and management of this condition. We aimed to determine the maternal and fetal outcomes of pregnancy in women with Fontan palliation.
Methods: This multicentric, retrospective study included women with Fontan circulation followed in 13 French specialized centers fromJanuary 2000 to June 2014. All pregnancieswere reviewed, including miscarriages, abortions, premature and term births. We reviewed maternal and fetal outcomes.
Results: Thirty-seven patients had 59 pregnancies. Mean age was 27 +/- 5 years at first pregnancy. There were 16 miscarriages (27%) and 36 live births with 1 twin pregnancy. Cardiac events occurred in 6 (10%) pregnancies, with no maternal death. The most common cardiac complication was atrial arrhythmia, which occurred in 3 patients. Hematological complications including thromboembolic/ hemorrhagic events (n = 3/7) occurred in 5 women antepartum (n = 2/3), and 4 women postpartum (n = 1/4). Two of the 3 thromboembolic events occurred in patients without anticoagulation. There was a high incidence of prematurity (n = 25/36, 69%). Anticoagulation was associated with adverse neonatal outcome (OR = 10.0, 95% CI [1.5-91.4], p < 0.01). After a median follow-up of 24 months, there was no significant worsening of clinical status and thromboembolic disease noted.
Conclusions: Pre-selected women can successfully complete pregnancy with Fontan circulation. There is an increase in cardiac and neonatal morbidity during pregnancy. Because thromboembolism could have a severe consequence on Fontan circulation, anticoagulation should be indicated during pregnancy and postpartum period.

• 出版日期2015-5-6