科研之友
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摘要
An efficient and simple new stereocontrolled access route to novel disubstituted cispentacin derivatives with multiple stereogenic centers from norbornene -lactam has been developed. The synthesis involves olefinic bond functionalization by dihydroxylation followed by oxidative ring cleavage and transformation of the dialdehyde intermediate through a Wittig reaction. Norbornenvazas -laktambol kiindulva sztereokontrollalt atalakitasokkal negy sztereogen centrumot tartalmazo diszubsztitualt ciszpentacin szarmazekokat allitottunk el. A szintezisut kulcslepesei a gyr szen-szen ketts kotesenek dihidroxilalasa, majd oxidativ gyrnyitast kovet Wittig reakcioval torten funkcionalizalasai voltak.
- 出版日期2013-2
