Molecular characterization of the first G24P[14] rotavirus strain detected in humans

作者：Ward M Leanne; Mijatovic Rustempasic Slavica; Roy Sunando; Rungsrisuriyachai Kunchala; Boom Julie A; Sahni Leila C; Baker Carol J; Rench Marcia A; Wikswo Mary E; Payne Daniel C; Parashar Umesh D; Bowen Michael D^*

来源：Infection, Genetics and Evolution, 2016, 43: 338-342.

DOI：10.1016/j.meegid.2016.05.033

• Rotavirus
• G24P[14]
• Bovine
• Reassortment

Here we report the genome of a novel rotavirus A (RVA) strain detected in a stool sample collected during routine surveillance by the Centers for Disease Control and Prevention's New Vaccine Surveillance Network. The strain, RVA/human-wt/USA/2012741499/2012/G24P[14], has a genomic constellation of G24-P[14]-I2-R2-C2-M2-A3-N2-T9-E2-H3. The VP2, VP3, VP7 and NSP3 genes cluster phylogenetically with bovine strains. The other genes occupy mixed clades containing animal and human strains. Strain RVA/human-wt/USA/2012741499/2012/G24P[14] most likely is the product of interspecies transmission and reassortment events. This is the second report of the G24 genotype and the first report of the G24P[14] genotype combination in humans. Published by Elsevier B.V.

• 出版日期2016-9