Ultrasound Current Source Density Imaging of the Cardiac Activation Wave Using a Clinical Cardiac Catheter

作者：Qin Yexian; Li Qian; Ingram Pier; Barber Christy; Liu Zhonglin; Witte Russell S^*

来源：IEEE Transactions on Biomedical Engineering, 2015, 62(1): 241-247.

DOI：10.1109/TBME.2014.2345771

• Acoustoelectric
• cardiac activation
• cardiac arrhythmia
• cardiac mapping
• electrocardiogram (ECG/EKG)

Ultrasound current source density imaging (UCSDI), based on the acoustoelectric (AE) effect, is a noninvasive method formapping electrical current in 4-D (space + time). This technique potentially overcomes limitationswith conventional electricalmapping procedures typically used during treatment of sustained arrhythmias. However, the weakAE signal associated with the electrocardiogram is a major challenge for advancing this technology. In this study, we examined the effects of the electrode configuration and ultrasound frequency on the magnitude of the AE signal and quality of UCSDI using a rabbit Langendorff heart preparation. The AE signal was much stronger at 0.5 MHz (2.99 mu V/MPa) than 1.0 MHz (0.42 mu V/MPa). Also, a clinical lasso catheter placed on the epicardium exhibited excellent sensitivity without penetrating the tissue. We also present, for the first time, 3-D cardiac activation maps of the live rabbit heart using only one pair of recording electrodes. Activationmaps were used to calculate the cardiac conduction velocity for atrial (1.31 m/s) and apical (0.67 m/s) pacing. This study demonstrated that UCSDI is potentially capable of realtime 3-D cardiac activation wave mapping, which would greatly facilitate ablation procedures for treatment of arrhythmias.

• 出版日期2015-1