Acquired immune response to defined Plasmodium vivax antigens in individuals residing in northern India

作者：Seth Ratanesh K; Bhat Ajaz A; Rao Donthamsetty N; Biswas Sukla^*

来源：Microbes and Infection, 2010, 12(3): 199-206.

DOI：10.1016/j.micinf.2009.12.006

• Malaria
• Plasmodium vivax
• Antigens
• Immune response

In this investigation, we evaluated the naturally acquired immune response to Plasmodium vinax stage-specific antigens in individuals of different age groups belonging to malaria endemic areas of northern India.
Four synthetic peptides containing both B- and T-cell epitopes from P. virax circumsporozoite protein, merozoite surface protein-1, apical membrane antigen-1 and gametocyte surface antigen-1 were used to determine both Immoral and cellular immune responses.
Immunity, in terms of antibody response and T-cell proliferation against these stage-specific peptides, has been observed in the study subjects. The results demonstrated age-dependent antibody response in this population. Forty two patients were diagnosed with P. vivax. There was a significant association (P=0.013) between number of antibody responders and recognition of stage-specific epitopes by antibodies. The antibody response to B-epitopes of P. vivax CSP, MSPI, AMAI and GAMI was associated with age; adults responded more frequently to these antigens than did younger children. In this population, 66% (201/304) cases showed seropositivity to all peptides and 13% (41/304) showed negative response. Peripheral blood mononuclear cells of more than 75% of individuals proliferated in response to stimulation by all four epitopes.
In conclusion, the results demonstrated immunogenicity of the epitopes to P. viva-v in population of this endemic zone.

• 出版日期2010-3
• 单位河北医科大学