Nanomaterial Based Approaches for the Diagnosis and Therapy of Cardiovascular Diseases

作者：Sharma Piyoosh A; Maheshwari Rahul; Tekade Muktika; Tekade Rakesh Kumar^*

来源：Current Pharmaceutical Design, 2015, 21(30): 4465-4478.

DOI：10.2174/1381612821666150910113031

• Cardiovascular diseases
• nanomaterials
• liposomes
• gold nanoparticles
• magnetic nanoparticles
• carbon nanotubes
• theranostics

The increasing prevalence and complexity of cardiovascular diseases demand innovative strategies for diagnostic and therapeutic applications to improve patient care/prognoses. Additionally, various factors constrain present cardiovascular therapies, including low aqueous drug solubility, early metabolism, short half-life and drug delivery limitations. The efficient treatment of cardiovascular diseases requires improvement of traditional drug delivery systems. This can be accomplished by using novel nanomaterial that can incorporate diverse bio-actives along with diagnostic agents in a single carrier, referred to as theranostics. This review discusses the state of the art in the applications to diagnosis and therapy of innovative, nanomaterial-based strategies such as lipid based carriers, nanocapsules, magnetic nanoparticles, gold nanoparticles, protein conjugated nanoparticles, dendrimers and carbon-based nanoformulations with a special emphasis on how they can contribute to improving the management of cardiovascular disease.

• 出版日期2015