Acetophenone azine: a new allergen responsible for severe contact dermatitis from shin pads

作者：Raison Peyron Nadia^*; Bergendorff Ola; Bourrain Jean Luc; Bruze Magnus

来源：Contact Dermatitis, 2016, 75(2): 106-110.

DOI：10.1111/cod.12579

• acetophenone azine
• allergic contact dermatitis
• chemical analysis
• EVA copolymers
• patch testing
• shin pads
• sport equipment
• CAS no. 729-43-1

Background. Contact dermatitis resulting from the use of shin pads is usually caused by rubber components, dyes, benzoyl peroxide, or formaldehyde resins.
Objectives. To investigate and identify a new allergen in shin pads that was responsible for severe contact dermatitis in a young football player.
Methods. High-performance liquid chromatography ( HPLC) of samples of shin pads was performed. The boy was patch tested with pieces of shin pads and with acetophenone azine, a chemical substance identified by HPLC in the foam of the shin pads.
Results. HPLC identified acetophenone azine at concentrations of approximately 20 mu g/g of shin pad samples. Patch tests gave strongly positive reactions to pieces of shin pads and to acetophenone azine down to 0.001% in acetone, whereas acetophenone and hydrazine sulfate were both negative. Twenty controls were negative for acetophenone azine 0.01% in acetone.
Conclusions. Acetophenone azine is a new, strong allergen of shin pads, and more generally of other sport equipment based on ethylene vinyl acetate. It may be used as a biocide, but this has to be confirmed. Further investigations are needed to understand factors such as exposure, cross-reaction patterns, metabolism, and the optimal patch test preparation.

• 出版日期2016-8