Association of high viral load and abnormal liver function with high aflatoxin B-1-albumin adduct levels in HIV-positive Ghanaians: preliminary observations

作者：Jolly P E^*; Shuaib F M; Jiang Y; Preko P; Baidoo J; Stiles J K; Wang J S; Phillips T D; Williams J H

来源：Food Additives and Contaminants Part A-Chemistry Analysis Control Exposure& Risk Assessment, 2011, 28(9): 1224-1234.

DOI：10.1080/19440049.2011.581698

• aflatoxins
• HIV
• liver function
• Ghana

We examined the association between certain clinical factors and aflatoxin B-1-albumin adduct (AF-ALB) levels in HIV-positive people. Plasma samples collected from 314 (155 HIV-positive and 159 HIV-negative) people were tested for AF-ALB levels, viral load, CD4+ T-cell count, liver function profile, malaria parasitaemia, and hepatitis B and C virus infections. HIV-positive participants were divided into high and low groups based on their median AF-ALB of 0.93 pmol mg(-1) albumin and multivariable logistic and linear regression methods used to assess relationships between clinical conditions and AF-ALB levels. Multivariable logistic regression showed statistically significant increased odds of having higher HIV viral loads (OR 2.84; 95% CI 1.17-7.78) and higher direct bilirubin levels (OR = 5.47; 95% CI = 1.03-22.85) among HIV-positive participants in the high AF-ALB group. There were also higher levels of total bilirubin and lower levels of albumin in association with high AF-ALB. Thus, aflatoxin exposure may contribute to high viral loads and abnormal liver function in HIV-positive people and so promote disease progression.

• 出版日期2011