Mechanism of acid hydrolysis of N-acetyl-D-glucosamine

作者：Dolgopyatova N V^*; Novikov V Yu; Konovalova I N; Putintsev N M

来源：Russian Journal of Applied Chemistry, 2013, 86(7): 986-991.

DOI：10.1134/S1070427213070070

The hydrolysis kinetics of the chitin monomer, N-acetyl-D-glucosamine, in HCl, HClO4, and H3PO4 was studied in relation to the acid concentration. The rate constants of N-acetyl-D-glucosamine deacetylation and D(+)-glucosamine formation in HClO4 and H3PO4 were determined for the first time. The rate of the acetamide bond hydrolysis in N-acetyl-D-glucosamine depends on the concentrations of hydrogen ions and water. The nucleophilicity of the acid residues does not affect the rate of N-acetyl-D-glucosamine hydrolysis.

• 出版日期2013-7
• 单位中国极地研究中心