A new approach for the asymmetric synthesis of (2S,3S)-3-hydroxypipecolic acid

作者：Liu, Liang-Xian^*; Peng, Qi-Long; Huang, Pei-Qiang

来源：Tetrahedron: Asymmetry , 2008, 19(10): 1200-1203.

DOI：10.1016/j.tetasy.2008.04.031

• STEREOSELECTIVE-SYNTHESIS
• 3-HYDROXYPIPECOLIC ACID
• PYRROLIDINE
• PIPERIDINE
• PYRIDINE
• ANALOGS

An efficient stereoselective synthesis of (2S,3S)-3-hydroxypipecolic acid was achieved from (S)-glutamic acid via the furylation of an N-protected 6-hydroxy-2-piperidinone using furan as a nucleophile and the oxidation of the furyl group to a carboxylic group as the key steps.

• 出版日期2008-5-30
• 单位赣南师范大学; 厦门大学