A Rapid and Nondestructive Method for the Prediction of Ibuprofen Tablet Hardness using NIR Diffuse Reflectance Spectroscopy

作者：Peng, Qiushi; Ba, Yi; Chen, Tingyu; Peng, Qianrong^*; Yang, Min^*

来源：Current Pharmaceutical Analysis, 2019, 15(5): 439-446.

DOI：10.2174/1573412914666180427092727

• Near-infrared diffuse reflectance spectroscopy
• IBU tablet
• hardness
• PLS
• PCR
• pharmaceutical

Introduction: This study aimed at developing a technology to measure the hardness of Ibuprofen (IBU) tablets and optimize the IBU formulation using Near-infrared (NIR) spectroscopy.
Materials and Methods: Tablets (400 mg +/- 5%, 10mm in diameter) consisting of IBU, microcrystalline cellulose SH-103, carboxymethyl starch sodium, magnesium stearate, silicon dioxide were formed of various hardness (2kg, 4kg, 6kg, 8kg, 10kg, 12kg). The reflectance NIR spectra of various tablets were employed to establish 9 calibrations models, which were further used to predict tablet hardness by Partial least squares (PLS) and principal component regression (PCR) analysis.
Results and Conclusion: Cross-validation with independent samples shows that PLS is the optimal predictive model. Which R2=0.9832, RSECV=0.334 and RSE=0.0669. This study established a new, simple, rapid, nondestructive and reliable methodology to optimize the IBU tablet hardness.

• 出版日期2019
• 单位贵州大学