Chromatographic study of complex formation of adamantane derivatives with beta-cyclodextrin

作者：Bazilin A V; Yashkina E A; Yashkin S N^*

来源：Russian Chemical Bulletin, 2016, 65(1): 103-109.

DOI：10.1007/s11172-016-1271-9

• adamantane derivatives
• complex formation
• beta~cyclodextrin
• gas liquid chromatography
• stability constants
• heat and entropy of complex formation

The thermodynamic characteristics for complex formation of molecules of the cage structure with beta-cyclodextrin (beta-CD) were determined using gas liquid chromatographic columns with glycerol and glycerol + beta-CD as with stationary liquid phases assuming equilibrium conditions at infinitely low sorbate concentrations in the gas phase. The influence of the nature and number of substituents in the adamantane fragment on the stability of the formed complexes was shown. Unlike adamantanes, the series of n-decane derivatives shows a decrease in chromatographic retention after addition of beta-CD to glycerol indicating the absence of strong interactions of the linear sorbates with beta-CD molecules. The parameters were determined for the regression equations relating the values of specific retention volumes to molecular parameters of sorbates such as polarizability, molar volume, liphophilicity, and others. The parameters of the derived equations were used for the determination of the relative contribution of various molecular descriptors to chromatographic retention of the adamantane derivatives on the sorbents studied.

• 出版日期2016-1