Scandium Triflate-Catalyzed Nucleophilic Additions to Indolylmethyl Meldrum's Acid Derivatives via a Gramine-Type Fragmentation: Synthesis of Substituted Indolemethanes

作者：Armstrong Erin L; Grover Huck K; Kerr Michael A^*

来源：Journal of Organic Chemistry, 2013, 78(20): 10534-10540.

DOI：10.1021/jo4017524

Treatment of indolylmethyl Meldrum's acids with catalytic scandium triflate and a variety of nucleophiles results in the nucleophilic displacement of the Meldrum's acid moiety via a gramine-type fragmentation. The reaction is useful for the generation of heterocyclic compounds of significant molecular complexity.

• 出版日期2013-10-18